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The SARS-CoV-2 pandemic has led to public health, economic, and social consequences that mandate urgent development of effective vaccines to contain or eradicate infection. To that end, we evaluated a novel amphiphile (AMP) vaccine adjuvant, AMP-CpG, composed of diacyl lipid-modified CpG, admixed with the SARS-CoV-2 Spike-2 receptor binding domain protein as a candidate vaccine (ELI-005) […]

Immune cells are naturally gifted in recognizing antigens and fighting off infection and disease. But, just like talented people, they need nurturing and the right training to fulfil their true potential. For immune cells this means a spell in lymph nodes— the training camps of the immune system—where they receive specialized instruction in the art of immune surveillance and attack.

Science – 2019
Ma L, Dichwalkar T, Chang JYH, et al.

Antitumor T-cell responses have the potential to be curative in cancer patients, but the induction of potent T-cell immunity through vaccination remains a largely unmet goal of immunotherapy.

Nature Medicine – 2016
Moynihan KD, Opel CF, Szeto GL, et al.

Nature – 2014
Liu H, Moynihan KD, Zhang Y, et al.

Nature