Orchestrating the immune Response

Engineering precision immunity

Elicio is committed to transforming the lives of patients and their families by re-engineering the body’s immune response to cancer. By combining expertise in materials science and immunology, Elicio is engineering potent Amphiphile immunotherapies including cell therapy activators, immunomodulators, and vaccines to defeat an array of aggressive cancers.


Lymph nodes:
where the immune response is orchestrated

Elicio was founded to expand and apply the ground-breaking Amphiphile technology invented and developed in the labs of Darrell Irvine, Ph.D., a Howard Hughes Medical Institute investigator and professor at the Koch Institute of Integrative Cancer Research at the Massachusetts Institute of Technology. Preclinical studies have demonstrated that Elicio’s Amphiphiles target and concentrate in the lymph nodes, resulting in unprecedented tumor-specific immune responses and durable cures of aggressive tumor models in mice.  Elicio is developing this approach to deliver next generation therapies, with lead programs in KRAS-driven cancers and CAR-T cell activators for CD19, BCMA, and multiple solid cancers. 





Our programs

Elicio will begin multiple Phase 1/2 studies for ELI-002 in 2020. This program consists of an Amphiphile vaccine that has the potential to elicit powerful immune responses against KRAS, a mutation found in 90% of pancreatic cancers, and 40% of colorectal cancers.



Latest News

ENDPOINTS: Christopher Haqq joins Elicio to hunt father’s RAS cancer
Christopher Haqq is now joining Elicio as its new R&D chief, overseeing the development of, among other things, their RAS-targeting immunotherapy. RAS mutations, which are now after 40 years of research becoming a prime target for experimental therapies, are present in about 30% of cancers, including 45% of colon cancers and nearly all pancreatic cancers. » Read more
FIERCE BIOTECH: Chutes and Ladders
Cambridge, Massachusetts-based Elicio Therapeutics has hired Christopher Haqq, M.D., Ph.D., as CMO and executive vice president and head of R&D. Haqq was the first employee and CMO of Atara Biotherapeutics, and later its CSO. » Read more