Orchestrating the immune Response

Engineering precision immunity

Elicio is committed to transforming the lives of patients and their families by re-engineering the body’s immune response to cancer. By combining expertise in materials science and immunology, Elicio is engineering potent Amphiphile immunotherapies including cell therapy activators, immunomodulators, and vaccines to defeat an array of aggressive cancers.


Lymph nodes:
where the immune response is orchestrated

Elicio was founded to expand and apply the ground-breaking Amphiphile technology invented and developed in the labs of Darrell Irvine, Ph.D., a Howard Hughes Medical Institute investigator and professor at the Koch Institute of Integrative Cancer Research at the Massachusetts Institute of Technology. Preclinical studies have demonstrated that Elicio’s Amphiphiles target and concentrate in the lymph nodes, resulting in unprecedented tumor-specific immune responses and durable cures of aggressive tumor models in mice.  Elicio is developing this approach to deliver next generation therapies, with lead programs in KRAS-driven cancers and CAR-T cell activators for CD19, BCMA, and multiple solid cancers. 





Our programs

Elicio will begin multiple Phase 1/2 studies for ELI-002 in 2020. This program consists of an Amphiphile vaccine that has the potential to elicit powerful immune responses against KRAS, a mutation found in 90% of pancreatic cancers, and 40% of colorectal cancers.



Latest News

Elicio Therapeutics to discuss novel lymph node vaccine targeting seven key mKRAS mutations at RAS – Targeted Drug Discovery Summit in Vienna, Austria
Elicio Therapeutics, a next generation immuno-oncology company, today announced Peter DeMuth, PhD., Elicio Vice President of Research, will present “Targeting the Lymph Nodes to Enhance Mutant KRAS-Specific Vaccine Responses,” at the upcoming RAS-Targeted Drug Discovery Summit in Vienna, Austria, from February 25 to 27, 2020. » Read more
Elicio Therapeutics and Natera To Collaborate in Phase I/II Pancreatic Cancer Study of ELI-002
Elicio Therapeutics and Natera, Inc.(NASDAQ: NTRA) today announced their collaboration in a prospective, multicenter Phase 1/2 study of ELI-002, an Amphiphile immuno-oncology therapeutic targeting KRAS mutations in the adjuvant setting for patients with pancreatic ductal adenocarcinoma (PDAC) who have undergone neoadjuvant chemotherapy followed by pancreatectomy. IND submission for the 108-patient trial which will open at 10-12 US sites will be in the first half of 2020. » Read more